Agranulocytosis after infectious mononucleosis

Tadafumi Yokoyama; Yuko Tokuhisa; Akiko Toga; Toshihiro Fujiki; Yasuhisa Sakakibara; Shintaro Mase; Raita Araki; Ryosei Nishimura; Taizo Wada; Tetsuya Fuseda; Eiji Kato; Akihiro Yachie

doi:10.1016/j.jcv.2012.11.016

Agranulocytosis after infectious mononucleosis

J Clin Virol. 2013 Mar;56(3):271-3. doi: 10.1016/j.jcv.2012.11.016. Epub 2012 Dec 20.

Authors

Tadafumi Yokoyama¹, Yuko Tokuhisa, Akiko Toga, Toshihiro Fujiki, Yasuhisa Sakakibara, Shintaro Mase, Raita Araki, Ryosei Nishimura, Taizo Wada, Tetsuya Fuseda, Eiji Kato, Akihiro Yachie

Affiliation

¹ Department of Pediatrics, Fukuiken Saiseikai Hospital, Wadanaka-machi, 7-1 Funahashi, Fukui, Fukui 918-8503, Japan. yokoyamaped@me.com

PMID: 23261081
DOI: 10.1016/j.jcv.2012.11.016

Abstract

We report the case of a 5-year-old boy with agranulocytosis after infectious mononucleosis (IM). Antibodies against anti-human neutrophil-specific antigens (HNA)-1 were detected in his serum. A literature review on agranulocytosis after IM and our case suggest that anti-HNA-1 antibodies play important roles in agranulocytosis associated with IM.

Publication types

Case Reports

MeSH terms

Agranulocytosis / diagnosis*
Autoantibodies / blood
Child, Preschool
Humans
Infectious Mononucleosis / complications*
Isoantigens / immunology
Male

Substances

Autoantibodies
Isoantigens
neutrophil-specific antigen NA1, human