Aluminum may mediate Alzheimer's disease through liver toxicity, with aberrant hepatic synthesis of ceruloplasmin and ATPase7B, the resultant excess free copper causing brain oxidation, beta-amyloid aggregation and Alzheimer disease

Med Hypotheses. 2013 Mar;80(3):326-7. doi: 10.1016/j.mehy.2012.11.036. Epub 2012 Dec 20.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adenosine Triphosphatases / metabolism*
  • Aluminum / toxicity*
  • Alzheimer Disease / enzymology
  • Alzheimer Disease / etiology*
  • Alzheimer Disease / metabolism
  • Amyloid beta-Peptides / metabolism*
  • Brain / drug effects*
  • Brain / metabolism
  • Ceruloplasmin / biosynthesis*
  • Humans
  • Liver / drug effects*
  • Liver / metabolism
  • Models, Theoretical
  • Oxidation-Reduction

Substances

  • Amyloid beta-Peptides
  • Aluminum
  • Ceruloplasmin
  • Adenosine Triphosphatases