An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases

Int J Mol Sci. 2012 Dec 24;14(1):434-56. doi: 10.3390/ijms14010434.


The endoplasmic reticulum (ER) is the major site of calcium storage and protein folding. It has a unique oxidizing-folding environment due to the predominant disulfide bond formation during the process of protein folding. Alterations in the oxidative environment of the ER and also intra-ER Ca2+ cause the production of ER stress-induced reactive oxygen species (ROS). Protein disulfide isomerases, endoplasmic reticulum oxidoreductin-1, reduced glutathione and mitochondrial electron transport chain proteins also play crucial roles in ER stress-induced production of ROS. In this article, we discuss ER stress-associated ROS and related diseases, and the current understanding of the signaling transduction involved in ER stress.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease*
  • Endoplasmic Reticulum Stress*
  • Humans
  • Models, Biological
  • Reactive Oxygen Species / metabolism
  • Unfolded Protein Response


  • Reactive Oxygen Species