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Review
. 2013 Mar;30(3):392-428.
doi: 10.1039/c2np20103h. Epub 2012 Dec 21.

A Genomic Approach to the Cryptic Secondary Metabolome of the Anaerobic World

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Review

A Genomic Approach to the Cryptic Secondary Metabolome of the Anaerobic World

Anne-Catrin Letzel et al. Nat Prod Rep. .

Abstract

A total of 211 complete and published genomes from anaerobic bacteria are analysed for the presence of secondary metabolite biosynthesis gene clusters, in particular those tentatively coding for polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS). We investigate the distribution of these gene clusters according to bacterial phylogeny and, if known, correlate these to the type of metabolic pathways they encode. The potential of anaerobes as secondary metabolite producers is highlighted.

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