A genomic approach to the cryptic secondary metabolome of the anaerobic world

Nat Prod Rep. 2013 Mar;30(3):392-428. doi: 10.1039/c2np20103h. Epub 2012 Dec 21.


A total of 211 complete and published genomes from anaerobic bacteria are analysed for the presence of secondary metabolite biosynthesis gene clusters, in particular those tentatively coding for polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS). We investigate the distribution of these gene clusters according to bacterial phylogeny and, if known, correlate these to the type of metabolic pathways they encode. The potential of anaerobes as secondary metabolite producers is highlighted.

Publication types

  • Review

MeSH terms

  • Bacteria* / chemistry
  • Bacteria* / genetics
  • Biological Products*
  • Humans
  • Metabolome*
  • Molecular Structure
  • Peptide Synthases / genetics
  • Peptide Synthases / metabolism
  • Polyketide Synthases / genetics
  • Polyketide Synthases / metabolism


  • Biological Products
  • Polyketide Synthases
  • Peptide Synthases