Tumor-infiltrating B cells and T cells: Working together to promote patient survival

Oncoimmunology. 2012 Dec 1;1(9):1623-1625. doi: 10.4161/onci.21650.


We recently reported a novel cooperative relationship between tumor-infiltrating B cells and CD8(+) T cells in ovarian cancer, leading to increased patient survival. Here, we discuss the mechanisms whereby B cells might enhance cellular immunity, including serving as antigen-presenting cells, organizing tertiary lymphoid structures and secreting polarizing cytokines. The enhancement of both B and T-cell responses may result in more potent and sustained antitumor immunity.