Abstract
A new actinomycete metabolite designated nosokophic acid was isolated from the culture broth of nosokomycin-producing Streptomyces sp. K04-0144, and the structure was elucidated by various NMR experiments. Nosokophic acid was found to be 3-phosphoglycosyl-2-sesquiterpenyl dihydroxypropionic acid, a predicted biosynthetic intermediate of nosokomycin-related moenomycins. The compound showed no activity against MRSA, but potentiated imipenem activity against MRSA by 512-fold.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Bambermycins / chemistry
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Bambermycins / metabolism*
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Drug Discovery*
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Drug Synergism
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Hexuronic Acids / chemistry*
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Hexuronic Acids / pharmacology
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Imipenem / pharmacology
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Magnetic Resonance Spectroscopy
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Organophosphates / chemistry*
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Organophosphates / pharmacology
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Streptomyces / chemistry
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Streptomyces / metabolism*
Substances
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3-phosphoglycosyl-2-sesquiterpenyl dihydroxypropionic acid
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Anti-Bacterial Agents
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Hexuronic Acids
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Organophosphates
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Bambermycins
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Imipenem