Long-term results of brachytherapy in early mobile tongue cancer with 10-year minimal follow-up

Anticancer Res. 2013 Jan;33(1):317-24.

Abstract

Aim: To retrospectively analyze the long-term toxicities of low-dose-rate interstitial brachytherapy (LDR-BT) with related prognostic factors for patients with early mobile tongue cancer (T1/2N0M0) at a minimum of 10 years' follow-up.

Patients and methods: The records of 187 patients treated with LDR-BT between 1980 and 2000, out of whom 25 were treated with additional prior external beam irradiation, were reviewed.

Results: Overall survival at 15 and 20 years was 88.4% and 76.2%, respectively. Complications included tongue ulcer (26%), tongue erosion (3%), tongue atrophy (2%), bone exposure (15%), and osteoradionecrosis (4%). No patient presented xerostomia or taste disorders. Multivariate analysis revealed that tongue ulcer and the use of spacer were significantly associated with bone exposure and osteoradionecrosis. Local recurrence was demonstrated in 15 (8%) cases, 93% of which were salvaged by operation. Fifty patients (27%) experienced neck metastasis.

Conclusion: LDR-BT is an acceptable treatment option, with low rates of long-term toxicity.

MeSH terms

  • Adult
  • Aged
  • Brachytherapy / adverse effects*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / etiology
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Staging
  • Osteoradionecrosis* / etiology
  • Osteoradionecrosis* / pathology
  • Radiation Dosage
  • Survival Rate
  • Tongue Diseases* / complications
  • Tongue Diseases* / pathology
  • Tongue Neoplasms* / complications
  • Tongue Neoplasms* / mortality
  • Tongue Neoplasms* / pathology
  • Tongue Neoplasms* / radiotherapy