Abstract
Protein-bound polysaccharide K (PSK) has been used as a chemoimmunotherapy agent for the treatment of colorectal cancer. Recently, PSK was reported to be able to decrease some adverse effects of FOLFOX therapy, including neutropenia and peripheral neurotoxicity. Here, we report 2 patients with metastatic colorectal cancer, who unexpectedly were able to receive many courses of PSK+mFOLFOX6 therapy for a prolonged period. We speculate that FOLFOX therapy may achieve long-term tumor control with the aid of PSK without serious side effects for metastatic colorectal cancer patients.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Colorectal Neoplasms / drug therapy*
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Colorectal Neoplasms / pathology
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Colorectal Neoplasms / surgery
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Combined Modality Therapy
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Female
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Fluorouracil / administration & dosage
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Humans
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Leucovorin / administration & dosage
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Liver Neoplasms / drug therapy*
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Liver Neoplasms / secondary
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Lung Neoplasms / drug therapy*
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Lung Neoplasms / secondary
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Middle Aged
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Organoplatinum Compounds / administration & dosage
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Polysaccharides / administration & dosage
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Time Factors
Substances
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Organoplatinum Compounds
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Polysaccharides
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Leucovorin
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Fluorouracil