The objective of the present study was to estimate the efficacy, safety, and tolerability of protracted therapy with sinuforte for 15 days in 40 patients presenting with medicamental rhinitis (MR). The secondary objective was to evaluate the long-term results of this treatment. The results of the study indicate that the efficacy of sinuforte therapy in the patients using nasal decongensants during 12 months amounts to 80.7%. This observation gives reason to recommend sinuforte as the product of choice for the treatment of the patients with medicamental rhinitis.