Dietary fibers reduce food intake by satiation without conditioned taste aversion in mice

Physiol Behav. 2013 Feb 17;110-111:13-9. doi: 10.1016/j.physbeh.2012.12.008. Epub 2012 Dec 23.

Abstract

It is well known that intake of dietary fiber (DF) potently decreases food intake and feelings of hunger and/or promotes satiety ratings. However, the mechanisms explaining these effects are not well characterized. This work was performed to determine which of satiation and/or satiety mechanisms provoke the decrease of food intake induced by DF in mice. We tested in an intra-group protocol a low-viscosity (LV, fructo-oligosaccharide), a viscous (VP, guar gum) and a high-viscosity (HV, mixture of guar gum and fructo-oligosaccharide) preload. These were given to mice by intra-gastric gavage. It appeared that viscous preloads such as VP and HV reduced the daily energy intake by 14% and 21% respectively. The strong effect of HV was mainly due to a large decrease of meal size (by 57%) and meal duration (by 65%) with no effect on ingestion rate during the first 30 min after administration. Therefore, the DF-induced decrease of energy intake was due to a satiation mechanism. This is further supported by a 3-fold increased sensitization of neurons in the nucleus of the solitary tract as observed by c-Fos protein immunolabelling. No compensation of food intake was observed during the rest of the day, a phenomenon that may be explained by the fact that metabolic rate remained high despite the lower food intake. We have also shown that the DF-induced inhibition of food intake was not paired with a conditioned taste aversion. To conclude, this work demonstrates that DF inhibits food intake by increasing satiation during ~1h after administration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Avoidance Learning
  • Carbon Dioxide / metabolism
  • Conditioning, Operant
  • Data Interpretation, Statistical
  • Diet
  • Dietary Fiber / administration & dosage
  • Dietary Fiber / pharmacology*
  • Eating / drug effects*
  • Energy Metabolism / drug effects
  • Immunohistochemistry
  • Intubation, Gastrointestinal
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Motor Activity / physiology
  • Oxygen Consumption / drug effects
  • Proto-Oncogene Proteins c-fos / metabolism
  • Respiratory Mechanics / drug effects
  • Satiation / drug effects*
  • Solitary Nucleus / drug effects
  • Solitary Nucleus / metabolism
  • Taste / drug effects*

Substances

  • Dietary Fiber
  • Proto-Oncogene Proteins c-fos
  • Carbon Dioxide