Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry

Nat Methods. 2013 Jan;10(1):28-34. doi: 10.1038/nmeth.2309.


Targeted mass spectrometry (MS) is becoming widely used in academia and in pharmaceutical and biotechnology industries for sensitive and quantitative detection of proteins, peptides and post-translational modifications. Here we describe the increasing importance of targeted MS technologies in clinical proteomics and the potential key roles these techniques will have in bridging biomedical discovery and clinical implementation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / analysis*
  • Biomedical Research*
  • Humans
  • Mass Spectrometry / methods*
  • Peptide Fragments / analysis*
  • Proteins / analysis*
  • Proteome / analysis*
  • Proteomics / methods*


  • Biomarkers
  • Peptide Fragments
  • Proteins
  • Proteome