Measurements of organic solvents in the work environment are carried out by either direct sampling using plastic bags/gas chromatography, solid sorbent adsorption using charcoal tubes/gas chromatography, or by a direct reading method using detector tubes. However, these methods cannot always measure the work environment accurately because the concentration of hazardous materials changes from time to time, and from space to space. In this study, the sensor characteristics of a real time monitor using a photoionization detector that can monitor vapor concentration continuously were investigated for 52 organic solvent vapors that are required to be measured in the work environment by the Ordinance of Organic Solvent Poisoning Prevention in Japan. The sensitivity of the monitor was high for the solvents with low ionization potential. However, the sensitivity for the solvents with high ionization potential was low, and the sensor could not detected 7 solvents. Calibration of the sensor using a standard gas was desirable before being used for measurement because the sensitivity of the sensor was variable.