Nursing guidelines for administration of immunoglobulin replacement therapy

J Infus Nurs. 2013 Jan-Feb;36(1):58-68. doi: 10.1097/NAN.0b013e3182798af8.


Immunoglobulin (Ig) replacement therapy, given as regular infusions of pooled human Ig, is the recognized treatment of humoral immunodeficiencies characterized by hypogammaglobulinemia and impaired antibody responses. It is a safe, effective therapy when delivered by nurses who have been educated to oversee and/or provide these infusions. Guidelines for administration have been developed by the Immune Deficiency Foundation Nurse Advisory Committee to provide a framework and guidance to those nurses administering this therapy.

MeSH terms

  • Humans
  • Immunoglobulins, Intravenous / administration & dosage*
  • Immunoglobulins, Intravenous / adverse effects
  • Immunoglobulins, Intravenous / therapeutic use
  • Immunologic Deficiency Syndromes / drug therapy*
  • Infusions, Subcutaneous
  • Nursing*
  • Practice Guidelines as Topic*


  • Immunoglobulins, Intravenous