The importance of cold-reactive autoantibodies in an asphyxiated infant before therapeutic hypothermia

Indian J Pediatr. 2013 Nov;80(11):962-4. doi: 10.1007/s12098-012-0941-3. Epub 2012 Dec 28.


Perinatal asphyxia is an important cause of neonatal morbidity and mortality. Hypothermia is an effective treatment of neonatal hypoxic-ischemic encephalopathy in infants. Cold agglutination is a primary or acquired autoimmune disease that involves autoantibodies that lead to hemagglutination at low temperatures lower than that of the body. In this case the importance of cold agglutinins during therapeutic hypothermia is presented.

Publication types

  • Case Reports

MeSH terms

  • Asphyxia Neonatorum / immunology*
  • Asphyxia Neonatorum / therapy*
  • Autoantibodies / immunology*
  • Cryoglobulins / analysis
  • Female
  • Humans
  • Hypothermia, Induced*
  • Infant, Newborn


  • Autoantibodies
  • Cryoglobulins
  • cold agglutinins