Hypertension-misattributed kidney disease in African Americans

Kidney Int. 2013 Jan;83(1):6-9. doi: 10.1038/ki.2012.369.

Abstract

Lipkowitz et al. extend the African American Study of Kidney Disease and Hypertension to the level of genetic epidemiology, in a case-control study design. Analysis of genotypes at the APOL1 kidney disease risk region supports a paradigm shift in which genetic risk is proximate to both kidney disease and hypertension. The findings mandate urgency in clarifying mechanisms whereby APOL1 region risk variants interact with environmental triggers to cause progressive kidney disease accompanied by dangerous hypertension.

Publication types

  • Comment

MeSH terms

  • African Americans / ethnology*
  • African Americans / genetics*
  • Apolipoprotein L1
  • Apolipoproteins / genetics*
  • Female
  • Genetic Variation / genetics*
  • Humans
  • Hypertension, Renal / ethnology*
  • Hypertension, Renal / genetics*
  • Kidney / physiopathology*
  • Lipoproteins, HDL / genetics*
  • Male
  • Nephritis / ethnology*
  • Nephritis / genetics*

Substances

  • APOL1 protein, human
  • Apolipoprotein L1
  • Apolipoproteins
  • Lipoproteins, HDL

Supplementary concepts

  • Hypertensive Nephropathy