Circulating Klotho levels: clinical relevance and relationship with tissue Klotho expression

Kidney Int. 2013 Jan;83(1):13-5. doi: 10.1038/ki.2012.370.


Klotho is a protein that exerts paracrine and endocrine functions. In chronic kidney disease (CKD), its expression is decreased in several tissues. This decrease probably plays important roles in various complications associated with CKD, in both a fibroblast growth factor-23 (FGF23)-dependent and an FGF23-independent manner. The clinical diagnosis of Klotho deficiency is not easy. The relevance of circulating Klotho levels, if any, needs to be adequately defined. Serum Klotho may not reflect tissue Klotho concentration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Female
  • Glucuronidase / blood*
  • Humans
  • Kidney / physiopathology*
  • Male
  • Renal Insufficiency, Chronic / blood*
  • Renal Insufficiency, Chronic / diagnosis*
  • Severity of Illness Index*


  • Glucuronidase
  • klotho protein