Rise of CC398 lineage of Staphylococcus aureus among Infective endocarditis isolates revealed by two consecutive population-based studies in France

PLoS One. 2012;7(12):e51172. doi: 10.1371/journal.pone.0051172. Epub 2012 Dec 13.


Staphylococcus aureus isolates from two prospective studies on infective endocarditis (IE) conducted in 1999 and 2008 and isolated from non-IE bacteremia collected in 2006 were spa-typed and their virulence factors were analyzed with a microarray. Both populations were genetically diverse, with no virulence factors or genotypes significantly more associated with the IE isolates compared with the non-IE isolates. The population structure of the IE isolates did not change much between 1999 and 2008, with the exception of the appearance of CC398 methicillin-susceptible Staphylococcus aureus (MSSA) isolates responsible for 5.6% of all cases in 2008. In 1999, this lineage was responsible for no cases. The increasing prevalence of S. aureus in IE is apparently not the result of a major change in staphylococcal population structure over time, with the exception of the emerging CC398 MSSA lineage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Endocarditis / microbiology*
  • Female
  • France
  • Genetic Variation
  • Genotype
  • Humans
  • Male
  • Methicillin Resistance
  • Methicillin-Resistant Staphylococcus aureus / classification
  • Methicillin-Resistant Staphylococcus aureus / genetics
  • Middle Aged
  • Oligonucleotide Array Sequence Analysis
  • Phylogeny
  • Staphylococcal Infections / classification
  • Staphylococcal Infections / epidemiology
  • Staphylococcus aureus / classification*
  • Staphylococcus aureus / genetics*
  • Virulence Factors / genetics


  • Virulence Factors

Grant support

The study was supported by a Programme Hospitalier de Recherche Clinique (clinical research program) funded by the French Ministry of Health. The funders had no role in study design, data collection and analysis, decision to publish, or manuscript preparation.