Neuropeptide Y stimulation as primary target for preventive measures of maladaptative cardiovascular reactions in occupational chronic stress exposure

Rev Med Chir Soc Med Nat Iasi. 2012 Jul-Sep;116(3):790-3.


Chronic stress may produce a decrease in central NPY expression and subjects exposed to it may prove hypersensitivity to a novel stressor with dysfunctions in the NPY system and cardiovascular maladaptation to stress, even hypertension. Upregulation of NPY expression may contribute to successful behavioral adaptation to stress by reducing cardiovascular tone and suppressing anxious behaviors. Adaptogens, a new class of metabolic regulators stimulate NPY expression and release. The aim of this study is to increase tolerance and adaptation to stress of hypersensitive to novel stressor, occupational chronic stress exposed subjects with cardiovascular maladaptation to mild new stressor using adaptogens as part of prevention protocol.

Material and methods: 40 military personnel with known cardiostressor reactional mode and occupational chronic stress exposure were exposed to mild novel stressor: occupational medicine routine evaluation and clinically assessed for maladaptative cardiovascular response prior and before application of 30 day prevention protocol. Employees were randomly split in two groups, one receiving standard prevention protocol (lifestyle counseling) plus adaptogens in multiple dose administration, twice daily and the other receiving only standard prevention protocol.

Results: We found significant statistic differences in all cardiovascular parameters in adaptogen group and only in diastolic blood pressure in control group.

Conclusions: Adaptogens could be an important factor in successful prevention protocols of chronic occupational stress dysfunctions involving NPY systems.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adaptation, Physiological / drug effects*
  • Adaptation, Psychological / drug effects*
  • Adult
  • Biomarkers / blood
  • Cardiovascular System / drug effects*
  • Cardiovascular System / physiopathology
  • Case-Control Studies
  • Chronic Disease
  • Counseling / methods
  • Eleutherococcus*
  • Fruit
  • Humans
  • Hypertension / physiopathology
  • Hypertension / prevention & control
  • Male
  • Middle Aged
  • Military Personnel
  • Neuropeptide Y / blood
  • Neuropeptide Y / drug effects*
  • Occupational Exposure / adverse effects*
  • Phytotherapy / methods
  • Plant Extracts / administration & dosage
  • Plant Extracts / therapeutic use*
  • Plant Roots
  • Rhodiola*
  • Risk Assessment
  • Schisandra*
  • Stress Disorders, Post-Traumatic / blood
  • Stress Disorders, Post-Traumatic / diagnosis
  • Stress Disorders, Post-Traumatic / drug therapy*
  • Stress Disorders, Post-Traumatic / physiopathology
  • Treatment Outcome


  • ADAPT 232
  • Biomarkers
  • Neuropeptide Y
  • Plant Extracts