Anti-angiogenesis in neuroblastoma

Crit Rev Oncol Hematol. 2013 Jun;86(3):212-21. doi: 10.1016/j.critrevonc.2012.11.004. Epub 2012 Dec 28.


The nature of the angiogenic balance in neuroblastoma is complex, and a spectrum of angiogenesis stimulators and inhibitors have been detected in neuroblastoma tumours. The complex relationships between angiogenic cascade and anti-angiogenic agents in the tumour vascular phase have indicated that anti-angiogenesis can be considered as a strategy for the adjuvant therapy of neuroblastoma. The major goal is to establish if inhibition of angiogenesis is a realistic therapeutic strategy for inhibiting tumour cell dissemination and the formation of metastasis in neuroblastoma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage
  • Angiogenesis Inhibitors / therapeutic use*
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / therapeutic use*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Genetic Therapy
  • Humans
  • Immunotherapy
  • Molecular Targeted Therapy
  • Neovascularization, Pathologic / drug therapy*
  • Neuroblastoma / blood supply*
  • Neuroblastoma / therapy*


  • Angiogenesis Inhibitors
  • Antineoplastic Agents