Chromatin organization: form to function

Curr Opin Genet Dev. 2013 Apr;23(2):185-90. doi: 10.1016/j.gde.2012.11.011. Epub 2012 Dec 26.

Abstract

Recent developments in technology have made it possible to create high resolution genome-wide maps of histone marks, DNA binding proteins and physical interactions along genomic regions. Chromatin features are found together in different combinations, dividing the genome up into domains with distinct functional properties. Microscopy and chromatin conformation capture techniques have shown that the 3D structure of chromosomes is constrained by nuclear features and functional links between different parts of chromatin. These results provide insights about the 3D and domain organization of the genome and their connection to gene regulation and other nuclear functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / genetics
  • Chromatin / genetics
  • Chromatin / ultrastructure*
  • Chromosomes / genetics
  • Chromosomes / ultrastructure*
  • DNA-Binding Proteins / genetics
  • Drosophila / genetics
  • Gene Expression Regulation
  • Genome*
  • Histones / genetics*
  • Histones / metabolism
  • Humans
  • Saccharomyces cerevisiae / genetics

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Histones