Giant-cell-rich pseudotumour in Paget's disease

Skeletal Radiol. 2013 Apr;42(4):595-9. doi: 10.1007/s00256-012-1558-3. Epub 2012 Dec 29.


Paget's disease (PD) of the bone is a disorder of bone remodelling that may be polyostotic or monostotic. Although development of a sarcoma in PD is well-recognised, it is less well recognised that pseudosarcomas in bone and soft tissue can also arise in this condition. In this report we document the case of a large giant-cell-rich pseudotumour that developed in the tibia and overlying soft tissues in a case of polyostotic PD. Bone and soft tissues were highly vascular and contained abundant haemorrhage with focal areas of new bone formation and a diffuse infiltrate of osteoclastic giant cells. The lesion has not recurred or produced metastases 3 years after removal. Clinicians should be aware that a benign giant-cell-rich pseudotumour can develop in PD and that it needs to be distinguished from other giant-cell-rich tumours.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bone Neoplasms / complications
  • Bone Neoplasms / diagnosis*
  • Bone Neoplasms / surgery
  • Diagnosis, Differential
  • Follow-Up Studies
  • Giant Cell Tumors / complications
  • Giant Cell Tumors / diagnosis*
  • Giant Cell Tumors / surgery
  • Giant Cells / diagnostic imaging
  • Giant Cells / pathology
  • Humans
  • Leg / diagnostic imaging
  • Leg / pathology
  • Leg / surgery
  • Male
  • Osteitis Deformans / complications*
  • Radiography
  • Soft Tissue Neoplasms / complications
  • Soft Tissue Neoplasms / diagnosis*
  • Soft Tissue Neoplasms / surgery
  • Tibia / diagnostic imaging
  • Tibia / pathology
  • Tibia / surgery
  • Treatment Outcome