PROSPER community-university partnership delivery system effects on substance misuse through 6 1/2 years past baseline from a cluster randomized controlled intervention trial

Prev Med. 2013 Mar;56(3-4):190-6. doi: 10.1016/j.ypmed.2012.12.013. Epub 2012 Dec 28.


Objective: To examine the effects of a delivery system for evidence-based preventive interventions through 12th grade, 6.5 years past baseline.

Method: A cohort sequential design included 28 public school districts randomly assigned to the partnership delivery system or usual-programming conditions. At baseline, 11,960 students participated. Partnerships supported community teams that implemented a family-focused intervention in 6th grade and a school-based intervention in 7th grade. Outcome measures included lifetime, current misuse, and frequencies of misuse, for a range of substances. Intent-to-treat, multilevel analyses of covariance of point-in-time misuse and analyses of growth in misuse were conducted.

Results: Results showed significantly lower substance misuse in the intervention group at one or both time points for most outcomes, with relative reduction rates of up to 31.4%. There was significantly slower growth in misuse in the intervention group for 8 of the 10 outcomes. In addition, risk moderation results indicated that there were significantly greater intervention benefits for higher- versus lower-risk youth, for the misuse of 6 of the 10 substances at 11th grade, illicit substances at 12th grade, and growth in the misuse of illicit substances.

Conclusion: Partnership-based delivery systems for brief universal interventions have potential for public health impact by reducing substance misuse among youth, particularly higher-risk youth.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Child
  • Cohort Studies
  • Community-Institutional Relations*
  • Female
  • Follow-Up Studies
  • Humans
  • Iowa / epidemiology
  • Male
  • Pennsylvania / epidemiology
  • Risk Assessment
  • Risk Reduction Behavior
  • School Health Services / organization & administration*
  • Substance-Related Disorders / epidemiology
  • Substance-Related Disorders / prevention & control*