Epigenetic flexibility in metabolic regulation: disease cause and prevention?

Trends Cell Biol. 2013 May;23(5):203-9. doi: 10.1016/j.tcb.2012.11.008. Epub 2012 Dec 29.


Metabolic diseases, including type 2 diabetes mellitus (T2DM), are increasing worldwide at an alarming rate. Epigenetic DNA modifications such as DNA methylation and histone modifications are thought to play an important role in the development of and predisposition to metabolic diseases. This review highlights the key functions of DNA methylation and histone modifications and elucidates the underlying mechanisms of in utero programming and epigenetic inheritance, which could account for the global increase in obesity and T2DM. The impact of exercise and nutrition on the tissue-specific epigenetic profile is discussed, because these lifestyle factors may modify epigenetic programming and predisposition to obesity and T2DM.

Publication types

  • Review

MeSH terms

  • DNA Methylation
  • Diabetes Mellitus, Type 2 / etiology
  • Diabetes Mellitus, Type 2 / genetics*
  • Environment
  • Epigenesis, Genetic*
  • Exercise
  • Female
  • Fetal Development / genetics
  • Fetal Growth Retardation
  • Genetic Predisposition to Disease
  • Histones / metabolism
  • Humans
  • Life Style
  • Maternal Nutritional Physiological Phenomena
  • Obesity / etiology
  • Obesity / genetics*
  • Pregnancy


  • Histones