BACE1 influences debris clearance and axonal regeneration in injured peripheral nerve

J Peripher Nerv Syst. 2012 Dec:17 Suppl 3:30-3. doi: 10.1111/j.1529-8027.2012.00428.x.

Abstract

During 3 years, my research activities in Jack Griffin's laboratory focused on the influence of β-amyloid precursor protein cleaving enzyme 1 (BACE1) on the degeneration/regeneration of sciatic nerve of mice. Here, potential mechanisms of how BACE1 enzymatic activity influences these processes are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amyloid Precursor Protein Secretases / metabolism*
  • Animals
  • Aspartic Acid Endopeptidases / metabolism*
  • Mice
  • Nerve Regeneration / physiology*
  • Peripheral Nerves / metabolism*
  • Phagocytosis / physiology*

Substances

  • Amyloid Precursor Protein Secretases
  • Aspartic Acid Endopeptidases
  • Bace1 protein, mouse