Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines

Virol J. 2013 Jan 2;10:1. doi: 10.1186/1743-422X-10-1.

Abstract

Herpesviridae is a large family of DNA viruses divided into three subfamilies: Alpha-, Beta- and Gammaherpesvirinae. The process of herpesvirus transmission is mediated by a range of proteins, one of which is glycoprotein L (gL). Based on our analysis of the solved structures of HSV2 and EBV gH/gL complexes, we propose that Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and Betaherpesvirinae UL130 originate from chemokines. Herpes simplex virus type 2 gL and human cytomegalovirus homolog (UL130) adopt a novel C chemokine-like fold, while Epstein-Barr virus gL mimics a CC chemokine structure. Hence, it is possible that gL interface with specific chemokine receptors during the transmission of Herpesviridae. We conclude that the further understanding of the function of viral chemokine-like proteins in Herpesviridae infection may lead to development of novel prophylactic and therapeutic treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alphaherpesvirinae / chemistry*
  • Alphaherpesvirinae / genetics
  • Amino Acid Sequence
  • Betaherpesvirinae / chemistry*
  • Betaherpesvirinae / genetics
  • Chemokines / chemistry*
  • Chemokines / genetics
  • Evolution, Molecular
  • Gammaherpesvirinae / chemistry*
  • Gammaherpesvirinae / genetics
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Conformation
  • Sequence Alignment
  • Viral Envelope Proteins / chemistry*
  • Viral Envelope Proteins / genetics

Substances

  • Chemokines
  • Viral Envelope Proteins