Ly-1 B cells and disease activity in (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation

Arthritis Rheum. 1990 Apr;33(4):553-62. doi: 10.1002/art.1780330413.


The treatment of female (New Zealand black x New Zealand white)F1 mice with total lymphoid irradiation resulted in a prolonged remission of autoimmune disease activity. Total lymphoid irradiation-treated mice also showed a marked reduction of Ly-1 B cells, which lasted up to 3 months. The subsequent return of Ly-1 B cells to preirradiation levels was not associated with a simultaneous return of disease when measured by parameters such as IgG anti-DNA antibodies and spontaneous secretion of IgG by splenic cells. In cell sorting experiments, most of the cells spontaneously secreting IgG were found within the Ly-1- (CD5-) splenic B cell population.

MeSH terms

  • Animals
  • Antigens, Ly / analysis*
  • Autoantibodies / biosynthesis
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / pathology
  • Autoimmune Diseases / radiotherapy
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / pathology
  • B-Lymphocytes / radiation effects
  • Cell Separation
  • DNA / immunology
  • Female
  • Flow Cytometry
  • Immunoglobulin G / biosynthesis
  • Immunoglobulin M / biosynthesis
  • Lymph Nodes / immunology
  • Lymph Nodes / pathology
  • Lymphatic Irradiation*
  • Mice
  • Mice, Inbred NZB
  • Peritoneal Cavity / cytology
  • Spleen / immunology
  • Spleen / pathology


  • Antigens, Ly
  • Autoantibodies
  • Immunoglobulin G
  • Immunoglobulin M
  • DNA