Coordinated reset has sustained aftereffects in Parkinsonian monkeys

Ann Neurol. 2012 Nov;72(5):816-20. doi: 10.1002/ana.23663.


Coordinated reset neuromodulation consists of the application of consecutive brief high-frequency pulse trains through the different contacts of the stimulation electrode. In theoretical studies, by achieving unlearning of abnormal connectivity between neurons, coordinated reset neuromodulation reduces pathological synchronization, a hallmark feature of Parkinson's disease pathophysiology. Here we show that coordinated reset neuromodulation of the subthalamic nucleus has both acute and sustained long-lasting aftereffects on motor function in parkinsonian nonhuman primates. Long-lasting aftereffects were not observed with classical deep brain stimulation. These observations encourage further development of coordinated reset neuromodulation for treating motor symptoms in Parkinson disease patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cross-Over Studies
  • Disease Models, Animal
  • Disease Progression
  • Electric Stimulation Therapy / methods
  • MPTP Poisoning / complications*
  • Macaca mulatta
  • Psychomotor Performance / physiology*
  • Subthalamic Nucleus / physiology
  • Treatment Outcome