Classification using NMR-based metabolomics of Sophora flavescens grown in Japan and China

Nat Prod Commun. 2012 Nov;7(11):1453-5.


We demonstrate that NMR-based metabolomics can be used to identify the country of growth (Japan or China) of Sophora flavescens plants. Principle Component Analysis (PCA) conducted on extracts of S. flavescens grown in China provided data distinct from that of extracts of plants grown in Japan. Loading plot analysis showed signals characteristic of Japanese S. flavescens. NMR analyses showed these signals to be due to kurarinol (1) and kushenol H (2). These compounds were confirmed by HPLC analysis to be distinctive markers for Japanese S. flavescens.

Publication types

  • Comparative Study

MeSH terms

  • China
  • Japan
  • Magnetic Resonance Spectroscopy
  • Metabolome
  • Principal Component Analysis
  • Sophora / classification
  • Sophora / metabolism*