Colchicine: an old wine in a new bottle?

Antiinflamm Antiallergy Agents Med Chem. 2013;12(1):14-23. doi: 10.2174/1871523011312010004.


Although colchicine, a natural product, is one of the oldest drugs still currently available, its possible functions seem to be surprisingly not well-known. Beyond its present medicinal use (gout, familial Mediterranean fever, Behcet's disease, chondrocalcinosis and other crystal arthritis), numerous other conditions have been recently proposed for the use of this drug, including pericardial diseases. However, colchicine appears as a double-edged sword, with underestimated toxicity and frequent side effects. In this review, we present the main pharmacologic features of this drug, with an emphasis on toxicity and highlight its possible applications in the cardiovascular field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Aged
  • Cardiovascular Diseases / drug therapy
  • Colchicine / adverse effects*
  • Colchicine / chemistry
  • Colchicine / pharmacokinetics
  • Colchicine / therapeutic use*
  • Female
  • Gout / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Pericarditis / drug therapy*
  • Randomized Controlled Trials as Topic
  • Treatment Outcome


  • Colchicine