Abstract
The organocatalytic Michael reaction of ketones with γ-monohalonitrodienes catalyzed by chiral prolinethiol ether under solvent-free conditions was developed. The described method represents a novel approach for accessing highly functionalized monohaloalkenes with α, β-stereocenters of up to >99% ee.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkenes / chemical synthesis*
-
Alkenes / chemistry*
-
Catalysis
-
Ether / chemistry*
-
Hydrocarbons, Halogenated / chemical synthesis*
-
Hydrocarbons, Halogenated / chemistry*
-
Molecular Structure
-
Proline / chemistry*
-
Solvents / chemistry*
-
Stereoisomerism
-
Sulfhydryl Compounds / chemistry*
Substances
-
Alkenes
-
Hydrocarbons, Halogenated
-
Solvents
-
Sulfhydryl Compounds
-
Ether
-
Proline