Cohesin in gametogenesis

Curr Top Dev Biol. 2013;102:1-34. doi: 10.1016/B978-0-12-416024-8.00001-5.

Abstract

Sister chromatid cohesion depends on cohesin, a tripartite complex that forms ring structures to hold sister chromatids together in mitosis and meiosis. Meiocytes feature a multiplicity of distinct cohesin proteins and complexes, some meiosis specific, which serve additional functions such as supporting synapsis of two pairs of sister chromatids and determining the loop-axis architecture of prophase I chromosomes. Despite considerable new insights gained in the past few years into the localization and function of some cohesin proteins, and the recent identification of yet another meiosis-specific cohesin subunit, a plethora of open questions remains, which concern not only fundamental germ cell biology but also the consequences of cohesin impairment for human reproductive health.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle Checkpoints
  • Cell Cycle Proteins / metabolism*
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Gametogenesis*
  • Humans
  • Kinetochores / metabolism
  • Meiosis
  • Oocytes / metabolism

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • cohesins