Characterization of muscarinic acetylcholine receptors in human labial salivary glands

Eur J Pharmacol. 1990 Feb 13;176(3):367-70. doi: 10.1016/0014-2999(90)90032-2.


Muscarinic acetylcholine receptors were studied in human labial salivary glands with (-)-[3H]MQNB. The radioligand bound with a Kd value of 150 pM. The density of muscarinic receptors was 220 fmol/mg protein. Most muscarinic antagonists bound to a homogeneous population of muscarinic receptors in this tissue. However, the inhibition curves of pirenzepine had a Hill slope of 0.57 and could be analyzed by a two site model. These results suggest that the muscarinic receptors in human labial salivary glands are a mixture of M1 and M3 types.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Humans
  • In Vitro Techniques
  • Kinetics
  • Models, Biological
  • Parasympatholytics / pharmacology
  • Quinuclidinyl Benzilate
  • Receptors, Muscarinic / drug effects*
  • Salivary Glands / drug effects
  • Salivary Glands / metabolism*


  • Parasympatholytics
  • Receptors, Muscarinic
  • Quinuclidinyl Benzilate