Importance of histological analysis of seroma fluid

Aesthetic Plast Surg. 2013 Feb;37(1):187-8. doi: 10.1007/s00266-012-0007-y. Epub 2013 Jan 4.


The recent observation of anaplastic large cell lymphoma (ALCL) in association with breast implants has initiated a large amount of literature recently, particularly in light of the issues with Poly Implant Prosthese implants. There are now approximately 35-50 reports of this lymphoma associated with breast implants. One of the presenting signs with this lymphoma is a late perimplant seroma. Given Kim et als recommendations for seroma fluid to be analysed, we suggest that all late seromas should be considered for analysis for the possible presence of a causative ALCL pathology, and add to the data currently available on this association.

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Publication types

  • Letter
  • Comment

MeSH terms

  • Breast Diseases / surgery*
  • Breast Implantation / adverse effects*
  • Breast Implants / adverse effects*
  • Female
  • Humans
  • Seroma / etiology*