Review of Ets1 structure, function, and roles in immunity

Cell Mol Life Sci. 2013 Sep;70(18):3375-90. doi: 10.1007/s00018-012-1243-7. Epub 2013 Jan 5.


The Ets1 transcription factor is a member of the Ets gene family and is highly conserved throughout evolution. Ets1 is known to regulate a number of important biological processes in normal cells and in tumors. In particular, Ets1 has been associated with regulation of immune cell function and with an aggressive behavior in tumors that express it at high levels. Here we review and summarize the general features of Ets1 and describe its roles in immunity and autoimmunity, with a focus on its roles in B lymphocytes. We also review evidence that suggests that Ets1 may play a role in malignant transformation of hematopoietic malignancies including B cell malignancies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alleles
  • Animals
  • Autoimmunity*
  • B-Lymphocytes / immunology*
  • Cell Transformation, Neoplastic
  • Chickens
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Killer Cells, Natural / immunology
  • Mice
  • Opossums
  • Protein Isoforms / immunology
  • Protein Isoforms / physiology
  • Proto-Oncogene Protein c-ets-1 / immunology
  • Proto-Oncogene Protein c-ets-1 / physiology*
  • SUMO-1 Protein / metabolism
  • T-Lymphocytes / immunology
  • Ubiquitin / metabolism


  • ETS1 protein, human
  • Protein Isoforms
  • Proto-Oncogene Protein c-ets-1
  • SUMO-1 Protein
  • SUMO1 protein, human
  • Ubiquitin