Histone chaperones in nucleosome assembly and human disease

Nat Struct Mol Biol. 2013 Jan;20(1):14-22. doi: 10.1038/nsmb.2461.


Nucleosome assembly following DNA replication, DNA repair and gene transcription is critical for the maintenance of genome stability and epigenetic information. Nucleosomes are assembled by replication-coupled or replication-independent pathways with the aid of histone chaperone proteins. How these different nucleosome assembly pathways are regulated remains relatively unclear. Recent studies have provided insight into the mechanisms and the roles of histone chaperones in regulating nucleosome assembly. Alterations or mutations in factors involved in nucleosome assembly have also been implicated in cancer and other human diseases. This review highlights the recent progress and outlines future challenges in the field.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Chromatin Assembly and Disassembly
  • DNA Replication*
  • Genomic Instability
  • Histone Chaperones / metabolism*
  • Histones / genetics
  • Histones / metabolism
  • Humans
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Nucleosomes / metabolism*


  • Cell Cycle Proteins
  • Histone Chaperones
  • Histones
  • Nucleosomes