Identification of a cadherin cell adhesion recognition sequence

Dev Biol. 1990 May;139(1):227-9. doi: 10.1016/0012-1606(90)90290-y.

Abstract

The molecular mechanisms by which the cadherins interact with one another to promote cell adhesion have not been elucidated. In particular, the amino acid sequences of the cadherin cell adhesion recognition sites have not been determined. Here we demonstrate that synthetic peptides containing the sequence HAV, which is common to all of the cadherins, inhibit two processes (compaction of eight-cell-stage mouse embryos and rat neurite outgrowth on astrocytes) that are known to be mediated by cadherins. The data suggest that the tripeptide HAV is a component of a cadherin cell adhesion recognition sequence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cadherins / analysis
  • Cadherins / pharmacology*
  • Cell Adhesion / drug effects
  • Cell Division / drug effects
  • Female
  • Mice
  • Oligopeptides / pharmacology
  • Structure-Activity Relationship

Substances

  • Cadherins
  • Oligopeptides