[Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging]

Adv Gerontol. 2012;25(3):478-82.
[Article in Russian]


The decrease of lymphocyte interferon gamma expression during aging is one of the main mechanisms leading to the immunodeficiency state in the elderly. Cell penetrating geroprotective peptide Ala-Glu-Asp-Gly has the capability to activate the proliferation of lymphocytes in thymus during its aging. The nucleotide sequence which is complementary contacted with peptide Ala-Glu-Asp-Gly was found in promoter region of interferon gamma gene. Thus, the immune protection of this peptide can be explained by its activation of the interferon gamma production in T-cells.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Aging / immunology*
  • Animals
  • Humans
  • Immunity, Innate / physiology*
  • Interferon-gamma / immunology*
  • Lymphocytes / immunology*
  • Lymphocytes / metabolism
  • Oligopeptides / immunology*
  • Oligopeptides / metabolism


  • Oligopeptides
  • Interferon-gamma
  • alanyl-glutamyl-aspartyl-glycine