Comparison of central venous catheter and peripheral vein samples of antibiotics in children with cystic fibrosis

J Spec Pediatr Nurs. 2013 Jan;18(1):33-41. doi: 10.1111/jspn.12006. Epub 2012 Nov 27.


PURPOSE.: To determine if accurate serum antibiotic levels can be obtained from central venous catheters (CVCs) in pediatric patients with cystic fibrosis. DESIGN AND METHODS.: Fifty paired CVC-peripheral vancomycin or tobramycin specimens were collected within 5 min of each other following a 5-ml flush and discard. Specimen samples were randomized by first site drawn. RESULTS.: CVC-peripheral antibiotic levels were highly correlated (r =.97, p <.001), with no statistically significant difference (t = 1.18, p =.25). Bland-Altman plot analysis revealed a bias of.47, with limits of agreement ranging from -4.20 to 6.87. PRACTICE IMPLICATIONS.: Accurate antibiotic concentrations can be obtained from CVCs, reducing pediatric patient trauma and stress.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Catheterization, Central Venous*
  • Catheterization, Peripheral*
  • Child
  • Child, Preschool
  • Cohort Studies
  • Cystic Fibrosis / diagnosis
  • Cystic Fibrosis / drug therapy*
  • Drug Monitoring / methods*
  • Female
  • Hospitals, Pediatric
  • Humans
  • Male
  • Sensitivity and Specificity
  • Specimen Handling
  • Tobramycin / administration & dosage
  • Tobramycin / blood*
  • Vancomycin / administration & dosage
  • Vancomycin / blood*


  • Vancomycin
  • Tobramycin