Metabolic makeover for HSCs

Matthew R Warr; Emmanuelle Passegué

doi:10.1016/j.stem.2012.12.005

Metabolic makeover for HSCs

Cell Stem Cell. 2013 Jan 3;12(1):1-3. doi: 10.1016/j.stem.2012.12.005.

Authors

Matthew R Warr¹, Emmanuelle Passegué

Affiliation

¹ The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Medicine, Hematology/Oncology Division, University of California at San Francisco, San Francisco, CA 94143, USA.

PMID: 23290130
DOI: 10.1016/j.stem.2012.12.005

Abstract

Hematopoietic stem cells (HSCs) must at times exit quiescence to divide and produce differentiated blood cells. In this issue of Cell Stem Cell, Takubo et al. (2013) and Yu et al. (2013) show that these opposing actions require distinct metabolic programs to meet the changing energy demands of self-renewing HSCs.

Publication types

Comment

Grants and funding

R01 HL111266/HL/NHLBI NIH HHS/United States