Keeping stem cells in check: a hippo balancing act

Cell Stem Cell. 2013 Jan 3;12(1):3-5. doi: 10.1016/j.stem.2012.12.004.


Knowing when to stop proliferation is crucial for any regenerative process. In a recent issue of Nature,Barry et al. (2012) report that the Hippo pathway component YAP negatively regulates Wnt signaling, thereby preventing stem cell overpopulation after a regenerative response in the intestine.

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