[Adult resident cardiomyocytes wake up: new axis for cardiac tissue regeneration]

Med Sci (Paris). 2012 Dec;28(12):1103-9. doi: 10.1051/medsci/20122812021. Epub 2012 Dec 21.
[Article in French]


All cardiomyopathies and more specifically myocardial infarction always evolve to cardiomyocytes death and the ensuing heart failure setting. So far, cardiac regenerative medicine has focused on the use of stem cells and completely ignored the resident cardiomyocytes, assumed in a postmitotic state. However, recent findings in zebrafish and mammalians challenge this view and suggest that these cells have some capacity to proliferate and can contribute to heart regeneration. In this review, we propose an overall synthesis about knowledge of the proliferative and regenerative capacities of resident cardiomyocytes, dealing with some mechanistic aspects. In the future, the accurate identification of molecular mechanisms allowing wake-up of resident cardiomyocyte proliferation will certainly open new therapeutic avenues in cardiac regeneration.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Adult Stem Cells / cytology
  • Adult Stem Cells / physiology*
  • Amphibians / physiology
  • Animals
  • Cell Differentiation / genetics
  • Cell Differentiation / physiology
  • Cellular Reprogramming / genetics
  • Cellular Reprogramming / physiology
  • Fishes / physiology
  • Heart / physiology*
  • Humans
  • Mammals / physiology
  • Models, Biological
  • Myocytes, Cardiac / metabolism
  • Myocytes, Cardiac / physiology*
  • Regeneration / genetics
  • Regeneration / physiology*
  • Signal Transduction / genetics
  • Signal Transduction / physiology