Emerging topics in the cell biology of mitogen-activated protein kinases

Trends Plant Sci. 2013 Mar;18(3):140-8. doi: 10.1016/j.tplants.2012.11.004. Epub 2013 Jan 4.


Signaling through mitogen-activated protein kinase (MAPK) cascades is organized in complex interconnected subcellular networks. Upon MAPK activation, signals are transferred to targets in different subcellular compartments able to regulate various cellular processes. Therefore, subcellular dissection of individual MAPK modules is vital to understand how a single MAPK can simultaneously mediate many tasks and how a single stimulus can direct different MAPK modules to separated tasks. In this opinion article, we present a subcellular localization prediction of all members of Arabidopsis thaliana MAPK modules validated wherever possible with experimental data. Furthermore, we propose, that at least in part, the complexity of plant MAPK signaling can be explained by unique strategies of subcellular targeting, which will be worth investigating in the near future.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Membrane / enzymology
  • Cytoplasm / enzymology
  • MAP Kinase Signaling System*
  • Mitogen-Activated Protein Kinases / metabolism*
  • Phosphorylation
  • Plant Physiological Phenomena
  • Plant Proteins / metabolism
  • Plants / enzymology*
  • Protein Transport
  • Software


  • Plant Proteins
  • Mitogen-Activated Protein Kinases