Administration of tomato juice ameliorates lactate dehydrogenase and creatinine kinase responses to anaerobic training

Food Chem Toxicol. 2013 Nov;61:9-13. doi: 10.1016/j.fct.2012.12.023. Epub 2013 Jan 3.


Creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH) are important biological markers of various myocardial disorders and exercise-induced muscle damage. Lycopene, on the other side, is a natural anti-oxidant with protective action against cardiovascular risk. Fifteen anaerobically trained athletes with elevated LDH and CPK baseline levels were enrolled in this study after undergoing thorough biochemical and cardiovascular evaluation with echocardiocraphy. In nine athletes tomato juice, a lycopene plain juice, was administered during and after exercise, replacing the carbohydrate supplementation beverages commonly used during training for over a 2-month period. Tomato juice administration significantly reduced LDH and CPK levels, which returned back to almost normal levels. At the same time homocysteine and C-reactive protein were also attenuated. No changes were observed in the control group, where the usual carbohydrate supplementation had been followed.

Keywords: Anaerobic training; Anti-oxidant; Creatinine phosphokinase; Lactate dehydrogenase; Lycopene.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Antioxidants / pharmacology*
  • Beverages*
  • C-Reactive Protein / metabolism
  • Creatine Kinase / blood*
  • Echocardiography
  • Exercise*
  • Female
  • Homocysteine / blood
  • Humans
  • L-Lactate Dehydrogenase / blood*
  • Male
  • Oxidative Stress / drug effects
  • Solanum lycopersicum*
  • Young Adult


  • Antioxidants
  • Homocysteine
  • C-Reactive Protein
  • L-Lactate Dehydrogenase
  • Creatine Kinase