Helminth mediated modulation of Type 1 diabetes (T1D)

Int J Parasitol. 2013 Mar;43(3-4):311-8. doi: 10.1016/j.ijpara.2012.12.004. Epub 2013 Jan 3.


Type 1 diabetes is increasing dramatically in incidence in the developed world. While there may be several reasons for this, improved sanitation and public health measures have altered our interactions with certain infectious agents such as helminths. There is increasing interest in the use of helminths or their products to alleviate inflammatory or allergic conditions. Using rodent models of diabetes, it has been possible to explore the therapeutic potential of both live infections as well as helminth-derived products on the development of autoimmunity. This review provides an overview of the findings from animal models and additionally explores the potential for translation to the clinic.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 1 / genetics
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 1 / parasitology
  • Diabetes Mellitus, Type 1 / therapy
  • Helminth Proteins / genetics
  • Helminth Proteins / immunology
  • Helminths / genetics
  • Helminths / immunology*
  • Helminths / physiology
  • Humans
  • Therapy with Helminths


  • Helminth Proteins