Reduction of trial-to-trial variability in functional near-infrared spectroscopy signals by accounting for resting-state functional connectivity

J Biomed Opt. 2013 Jan;18(1):17003. doi: 10.1117/1.JBO.18.1.017003.

Abstract

The reduction of trial-to-trial variability (TTV) in task-evoked functional near-infrared spectroscopy signals by considering the correlated low-frequency spontaneous fluctuations that account for the resting-state functional connectivity in the brain is investigated. A resting-state session followed by a task-state session of a right hand finger-tapping task has been performed on five subjects. Significant ipsilateral and bilateral resting-state functional connectivity has been detected at the subjects' motor cortex using the seed correlation method. The correlation coefficients obtained during the resting-state are used to reduce the TTV in the signals measured during the task sessions. The results suggest that correlated spontaneous low-frequency fluctuations contribute significantly to the TTV in the task evoked fNIRS signals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain / blood supply
  • Brain / metabolism
  • Brain / physiology
  • Brain Mapping / methods*
  • Hemoglobins / analysis
  • Humans
  • Male
  • Oxygen / blood
  • Oxyhemoglobins / analysis
  • Signal Processing, Computer-Assisted*
  • Spectroscopy, Near-Infrared / methods*
  • Task Performance and Analysis

Substances

  • Hemoglobins
  • Oxyhemoglobins
  • deoxyhemoglobin
  • Oxygen