Identifying RNA editing sites using RNA sequencing data alone

Nat Methods. 2013 Feb;10(2):128-32. doi: 10.1038/nmeth.2330. Epub 2013 Jan 6.


We show that RNA editing sites can be called with high confidence using RNA sequencing data from multiple samples across either individuals or species, without the need for matched genomic DNA sequence. We identified many previously unidentified editing sites in both humans and Drosophila; our results nearly double the known number of human protein recoding events. We also found that human genes harboring conserved editing sites within Alu repeats are enriched for neuronal functions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / genetics
  • Alu Elements
  • Animals
  • Computational Biology / methods
  • Drosophila melanogaster / genetics
  • Humans
  • Inosine / genetics
  • RNA Editing*
  • Sequence Analysis, RNA / methods*


  • Inosine
  • Adenosine

Associated data

  • GEO/GSE42815