Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 43 (12), 1355-64

Review of the Alterations in DNA Methylation in Esophageal Squamous Cell Carcinoma


Review of the Alterations in DNA Methylation in Esophageal Squamous Cell Carcinoma

Yoshifumi Baba et al. Surg Today.


Epigenetic changes such as DNA methylation, histone modification, and loss of genome imprinting play a crucial role in esophageal squamous cell carcinogenesis, along with genomic and genetic alterations. DNA methylation is a fundamental epigenetic process that modulates gene expression. Cancer cells exhibit two types of alterations of DNA methylation: global DNA hypomethylation and site-specific CpG island promoter hypermethylation. In several types of human cancers, the methods of detecting an aberrant methylation status have been applied to clinical fields to stratify high-risk groups, detect early cancer, and predict clinical outcomes. Importantly, epigenetic changes, including alterations in DNA methylation, are reversible and can thus be targets for cancer therapy or chemoprevention. Therefore, a better understanding of the DNA methylation in esophageal squamous cell carcinoma (ESCC) is important for optimizing cancer therapy and chemoprevention. We herein summarize the current knowledge regarding alterations in DNA methylation and the clinical implications in ESCC.

Similar articles

See all similar articles

Cited by 19 articles

See all "Cited by" articles


    1. Nat Rev Drug Discov. 2005 Apr;4(4):275-6 - PubMed
    1. Science. 2003 Apr 18;300(5618):455 - PubMed
    1. World J Gastroenterol. 2011 Oct 7;17(37):4225-30 - PubMed
    1. Oncogene. 2007 Aug 30;26(40):5927-38 - PubMed
    1. Int J Cancer. 2006 Sep 1;119(5):1023-7 - PubMed

Publication types

MeSH terms

LinkOut - more resources