[Effects of inhibitory activity on mycelial growth of Candida albicans and therapy for murine oral candidiasis by the combined use of terpinen-4-ol and a middle-chain fatty acid, capric acid]

Yakugaku Zasshi. 2013;133(1):133-40. doi: 10.1248/yakushi.12-00242.
[Article in Japanese]


The combined effect of terpinen-4-ol, the main component of tea tree oil, and capric acid against mycelial growth of Candida albicans and murine oral candidiasis was evaluated in vitro and in vivo. Mycelial growth of C. albicans was estimated by the Cristal violet method. Combination of these compounds revealed a potent synergistic inhibition of growth. Therapeutic efficacy of the combination was evaluated microbiologically in murine oral candidiasis, and its application of the compounds clearly demonstrated therapeutic activity. Based on these results, the combined agent of terpinen-4-ol and capric acid was discussed as a possible candidate for oral candidiasis therapy.

MeSH terms

  • Animals
  • Antifungal Agents / administration & dosage*
  • Antifungal Agents / pharmacology*
  • Candida albicans / drug effects*
  • Candida albicans / growth & development*
  • Candidiasis, Oral / drug therapy*
  • Candidiasis, Oral / microbiology*
  • Decanoic Acids / administration & dosage*
  • Decanoic Acids / pharmacology*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Resistance, Fungal
  • Drug Synergism
  • Drug Therapy, Combination
  • Mice
  • Mice, Inbred ICR
  • Terpenes / administration & dosage*
  • Terpenes / pharmacology*


  • Antifungal Agents
  • Decanoic Acids
  • Terpenes
  • decanoic acid
  • terpinenol-4