A fast protocol for infarct quantification in mice

J Magn Reson Imaging. 2013 Aug;38(2):468-73. doi: 10.1002/jmri.24001. Epub 2013 Jan 4.


Purpose: To demonstrate and validate a late gadolinium enhancement (LGE) imaging protocol, optimized for tissue viability assessment in interventional mouse models of myocardial infarction.

Materials and methods: The method uses an efficient sampling scheme using multiple slices in a single heartbeat interleaving slice packages between alternate TRs. Sampling multiple slices instead of multiple echoes or multiple k-lines achieves higher SNR efficiency, and images covering the whole heart can be obtained in 3 min. Saturation effects are exploited for an optimum compromise between contrast and speed.

Results: The images obtained show high hyperenhancement with good contrast-to-noise. It is shown that inversion time optimization can be reliably omitted with this scheme, and that measured infarct sizes correlate well with histological measures.

Conclusion: Our protocol offers a new efficient tool for the measurement of infarct size in mouse models of heart disease.

Keywords: TI optimization; ischemia; late gadolinium enhancement (LGE); myocardial infarction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Algorithms*
  • Animals
  • Contrast Media
  • Feasibility Studies
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted / methods*
  • Magnetic Resonance Imaging, Cine / methods*
  • Mice
  • Myocardial Infarction / pathology*
  • Organometallic Compounds*
  • Reproducibility of Results
  • Sensitivity and Specificity


  • Contrast Media
  • Organometallic Compounds
  • gadobutrol