Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients

Crit Care. 2013 Jan 8;17(1):402. doi: 10.1186/cc11886.

Abstract

Analyzing medical records of 979 patients with severe sepsis or septic shock provided some evidence that the use of low-dose aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) was associated with decreased hospital mortality. However, the benefit was abolished when aspirin and NSAIDs were given together.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
  • Aspirin / administration & dosage*
  • Clopidogrel
  • Dose-Response Relationship, Drug
  • Female
  • Hospital Mortality*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Intensive Care Units
  • Length of Stay*
  • Male
  • Middle Aged
  • Platelet Aggregation Inhibitors / therapeutic use
  • Sepsis / drug therapy*
  • Sepsis / mortality*
  • Ticlopidine / analogs & derivatives
  • Ticlopidine / therapeutic use

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Platelet Aggregation Inhibitors
  • Clopidogrel
  • Ticlopidine
  • Aspirin